Differin GelAdapaleneGalderma. Rx quality 30g 0.10% . Adapalene is used to treat acne. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin.Adapalene comes as a gel, a solution (liquid), and a cream to apply to the skin. The solution comes in a glass bottle with an applicator and as individual pledgets (medicated wipes for one time use). It is usually applied once a day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor .